How Disordered Breathing Impacts Cognition & Dementia Risk

Common Cognitive Symptoms of Low CO2 Levels

When you breathe too much or too fast for too long, due to learned behaviors of breathing, you body loses too much carbon dioxide (CO2) and this affects the way your brain functions.

An ongoing heightened central nervous system hijacked by a state of hypervigilance or survival will create the perfect storm that will yield thought patterns that are destructive and negative. These patterns can perpetuate and exacerbate with more stress, creating true pathological conditions as mental health disorders.  Your sense of ease, motivation, and confidence can be negatively affected by the way you breath. CO2 depletion can cause the following states:

How Low CO2 Affects Your Brain

The brain needs oxygen and blood flow to thrive. It is common to think that the way you breathe can affect your brain function. Breathing dysfunction can lead to CO2 depletion, resulting in impaired oxygen delivery, and decreased blood flow to the brain and all organs and systems in the body.

Carbon dioxide (CO2) is often perceived merely as a waste product of respiration. However, maintaining appropriate CO2 levels is crucial for various bodily functions, including oxygen transport, blood flow, and decreased inflammation.

Mechanisms Linking Low CO2 levels to Dementia

The connection between low CO2 levels and dementia may involve several mechanisms:

1. Decreased Blood Blow To The brain

Low CO2 makes your blood vessels tighten, reducing blood flow. WHY IT MATTERS: Your brain gets less blood volume and less oxygen. This can make you feel dizzy, tired, foggy, or like your thinking is slower than usual. Decreased blood flow is also referred to as cerebral hypoperfusion, and this is a known risk factor for vascular dementia.

2. Poor Oxygen Delivery (Bohr Effect)

Low CO2 makes it harder for red blood cells to release oxygen. WHY THIS MATTERS: Oxygen is not available when you have low CO2 levels. You can attempt to breathe deeper trying to get enough oxygen, but your brain can't use the oxygen effectively.

3. Neurotransmitter Imbalance

A neurotransmitter imbalance means the brain's chemical messengers are not working correctly.

WHY IT MATTERS: A neurotransmitter is a small chemical messenger that helps brain cells talk to each other.

For those who are interested in science, let me provide a brief explanation of what exactly happens when breathing dysfunction causes low CO2 levels and brain chemical imbalance.

Imbalance occurs when some messengers are too high or too low. This can affect how you feel, think, sleep, and handle stress. For example, neurotransmitters that are too high can cause brain cells to get over-stimulated. This can cause anxiety, restlessness, mind racing, trouble sleeping, or feeling "on edge." Conversely, if there are too few messengers (too low) communication between the cells slow down. This can lead to tiredness, sadness, or brain fog.

Hypocapnia, low CO2 levels, can alter the balance of glutamate and gamma-aminobutyric acid (GABA), which are critical for cognitive processes. Essentially, glutamate speeds things up in your thinking. The brain cells in your brain get more active. On the other hand, GABA slows things down, and this can help you feel calm and focused.

When CO2 levels are too low from over-breathing or stress, the brain gets too much glutamate and not enough GABA. That means your brain stays in "go-go-go" mode, making it hard to relax, sleep, or feel steady. Disruptions in these neurotransmitters have been implicated in various forms of dementia.

4. Cell Damage - Oxidative Stress

Low CO2 can interfere with how cells use oxygen, creating harmful molecules called free radicals. Essentially, oxidative stress happens when your body has too many harmful molecules (free radicals) and not enough defenses to clean them up.

WHY IT MATTERS: This can result in damage to the cells. It is like your cells are getting "rusty" or damaged inside and very little to no repair process.

Lowered CO2 levels causes the oxygen to not be available to nourish the cells. The cells in your brain cannot use oxygen properly, leading to neuronal damage and contributing to the onset of neurodegenerative diseases like dementia and Alzheimer's disease.

5. Low Brain Energy (Mitochondria Dysfunction)

Mitochondria are the energy factories in your cells and they need balance CO2 to work well. Low CO2 affects the release of oxygen from red blood cells. The oxygen is not available to combine with glucose to produce ATP (Cellular energy) in the cells.

WHY THIS MATTERS: Low CO2 results in mitochondria dysfunction. Without enough CO2, your brain makes less energy, which can lead to fatigue, poor memory, confusion, disorientation, and depersonalization.

6. Inflammation and Immune Stress

Low CO2 can trigger inflammation in the brain and body. Low CO2 confuses the brain into thinking there is a problem. It is like the smoke alarms are triggered even if there is no real fire. The smoke alarm sends out inflammation signals, just like calling firefighters, but the alarms keep going off for no reason long after the firefighters cleared the area. Low CO2 caused by breathing dysfunction will keep setting off false alarms in your brain, creating more inflammation and causing more cell damage to the brain.

Clinical Observation and Preventative Measures

Clinical reports have documented cases where patients with hyperventilation syndrome (HVS), characterized by chronic hyperventilation and resultant low CO2, presented with cognitive impairments. With the proper treatment aimed at normalizing breathing patterns and CO2  levels, the patient’s cognitive functions can improve, suggesting a reversible component of CO2 related cognitive impairments. In other words, the treatment aims at restoring blood supply, oxygen delivery, and decreasing inflammation.

Recognizing the impact of CO2 levels on cognitive health underscores the importance of proper breathing techniques and respiratory health in preventing cognitive decline. Interventions may include:

• Breathing Retraining: Teaching individuals to adopt appropriate breathing patterns can help maintain optimal CO2 levels, potentially mitigating cognitive risks associated with hypocapnia.
• Anxiety Management: Since anxiety can lead to hyperventilation, addressing anxiety through therapeutic approaches may prevent exacerbation of disordered breathing and its cognitive consequences.
• Regular Monitoring: For individuals with respiratory disorders, regular monitoring of CO2  levels could aid in early detection and management of potential cognitive impairments.

Conclusion

• Low CO2 isn't harmless. It is a hidden stressor in the brain.
• Maintaining balanced CO2 levels is essential not only for respiratory function but also for cognitive health.
• Hypocapnia, often resulting from hyperventilation, can lead to significant cognitive impairments and may contribute to the development or exacerbation of dementia.
• Restoration of CO2 balance is a critical component of physiological rehabilitation, which can lead to predictable recovery or improvement of symptoms.

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At Respiras, we specialize in restoring breathing patterns  and CO2 balance to increase blood flow and oxygen to the brain. By understanding and addressing the role of CO2 in cognitive function, we can take proactive steps toward preserving cognitive health and enhance longevity.

 

 

 

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